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NORDIHYDROGUAIARETIC ACID |
| Synonyms. Nordihydroguaiaretic acid; 2,3-Bis(3,4-dihydroxyphenylmethyl)butane; 2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol); 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol); 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane; Dihydronorguaiaretic acid; NDGA; Nordihydroguairaretic acid; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane; Masoprocol; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
500-38-9 |
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EINECS RN |
207-903-0 |
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FORMULA |
[CH(CH3)CH2C6H3-1,2-(OH)2]2 |
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MOLE WEIGHT |
302.36 |
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H.S CODE |
2907.29.9000 |
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SMILES |
c1(ccc(O)c(c1)O)C[C@@H]([C@@H](Cc1cc(c(cc1)O)O)C)C |
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CLASSIFICATION |
Analgesic, Anti-Inflammatory, Enzyme Inhibitor, Phenol antioxidant, Phenylpropanoid |
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EXTRA NOTES |
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
off-white to beige powder |
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MELTING POINT |
184 ~ 187 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
4.64 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Nordihydroguaiaretic acid Wikipedia Linking - Nordihydroguaiaretic acid Google Scholar Search - Nordihydroguaiaretic acid U.S. National Library of Medicine - Nordihydroguaiaretic acid PubChem Compound Summary - Nordihydroguaiaretic acid KEGG (Kyoto Encyclopedia of Genes and Genomes) - Nordihydroguaiaretic acid http://www.ncbi.nlm.nih.gov/ - Nordihydroguaiaretic acid Material Safety Data Sheet - Nordihydroguaiaretic acid EPA - Substance Registry Services - Nordihydroguaiaretic acid |
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| SALES SPECIFICATION | |
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APPEARANCE |
off-white to beige powder |
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ASSAY |
99% min |
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MELTING POINT |
184 ~ 186 C |
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LOSS ON DRYING |
0.5% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity Oral, Skin irritation, Eye irritation, Specific target organ toxicity - single exposure. Hazard statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H302-H315-H319-H335 |
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P STATEMENTS |
P261-P305 + P351 + P338 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
22-36/37/38 |
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SAFETY PHRASES |
26-36/37 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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